"The Last Lecture" is a series of reflections Dr. Pausch had on his life. Branching out from a lecture he gave at CMU, he goes on to tell the reader about what made him tick, and what helped him in his fight with terminal cancer.
Some other reviewers panned the book for being somewhat self-aggrandizing, but Pausch knew he wasn't perfect. He knew that there was much he could have done differently. And he just seems to have been a likeable guy. He knew to not have many regrets for himself, but to realize that his cancer affected many more people than just him.
This book was a beautiful coda to his battle. It is up to the reader to decide if there are any lessons worth taking from the book to make yourself a better person. And you're just not human if you aren't at least a little moved toward the end.